SDF4 and NR1I2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SDF4	NR1I2
Description		stromal cell derived factor 4	nuclear receptor subfamily 1 group I member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Plasma Membrane Membrane Bleb Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Body Intermediate Filament Cytoskeleton RNA Polymerase II Transcription Factor Complex
	Molecular Function	Calcium Ion Binding Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	UV Protection Calcium Ion Regulated Exocytosis Cerebellum Development Fat Cell Differentiation Response To Ethanol Zymogen Granule Exocytosis	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Xenobiotic Metabolic Process Signal Transduction Multicellular Organism Development Steroid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Response To Lipid Cholesterol Homeostasis Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Lipopolysaccharide
Pathways
Drugs			Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Progesterone Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinyl Estradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Chenodeoxycholic acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Medication use (thyroid preparations) ( 31015401)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Total cholesterol levels ( 30275531)
Interacting Genes		12 interacting genes: ANXA7 APP CDKN1A NR1I2 RAP1B RCC1 RPA2 SMN1 SNCA TK1 TTR ZNF512B	32 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5
Entrez ID		51150	8856
HPRD ID		13113	04346
Ensembl ID		ENSG00000078808	ENSG00000144852
Uniprot IDs		A0A024R084 A0A024R0A9 Q9BRK5	F1D8P9 O75469
PDB IDs			1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6S41
Enriched GO Terms of Interacting Partners?
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