FIS1 and DNM1L

Number of citations of the paper that reports this interaction (PubMedID 12861026)
265

Data Source:
HPRD (in vitro, in vivo)

		FIS1	DNM1L
Description		fission, mitochondrial 1	dynamin 1 like
Image
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Outer Membrane Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Membrane Cell Junction Synaptic Vesicle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynaptic Endocytic Zone Membrane Mitochondrion-derived Vesicle
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Rab GTPase Binding Clathrin Binding GTP-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding BH2 Domain Binding
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Cellular Response To Thapsigargin Response To Flavonoid Response To Hypobaric Hypoxia Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Calcium Ion Transport Mitochondrion Organization Endoplasmic Reticulum Organization Apoptotic Mitochondrial Changes Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Synaptic Vesicle Recycling Via Endosome Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Organelle Fission Intracellular Distribution Of Mitochondria Synaptic Vesicle Endocytosis Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Positive Regulation Of Dendritic Spine Morphogenesis Membrane Fusion Protein-containing Complex Assembly Necroptotic Process Mitochondrion Morphogenesis Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Oxygen-glucose Deprivation Execution Phase Of Apoptosis Regulation Of Peroxisome Organization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Cellular Response To Thapsigargin Regulation Of Ubiquitin Protein Ligase Activity Response To Flavonoid Response To Hypobaric Hypoxia Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Class I peroxisomal membrane protein import	Apoptotic execution phase
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 30891314)
Interacting Genes		11 interacting genes: A2M BCAP31 CREB3 DNM1L KASH5 MARCHF5 NOS3 PEX5 TBC1D15 UBC VKORC1	20 interacting genes: FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 VIM ZBTB24
Entrez ID		51024	10059
HPRD ID		12352	04833
Ensembl ID		ENSG00000214253	ENSG00000087470
Uniprot IDs		Q9Y3D6	B4DYR6 O00429
PDB IDs		1NZN 1PC2	3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9
Enriched GO Terms of Interacting Partners?
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