MED31 and GADD45G

Number of citations of the paper that reports this interaction (PubMedID 15383276)
142

Data Source:
HPRD (two hybrid, in vitro)

		MED31	GADD45G
Description		mediator complex subunit 31	growth arrest and DNA damage inducible gamma
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Automobile speeding propensity ( 30643258) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	55 interacting genes: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579
Entrez ID		51003	10912
HPRD ID		14382	05383
Ensembl ID		ENSG00000108590	ENSG00000130222
Uniprot IDs		Q9Y3C7	O95257
PDB IDs			2WAL 3FFM
Enriched GO Terms of Interacting Partners?
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