PBX1 and HOXB1

Number of citations of the paper that reports this interaction (PubMedID 10052460)
98

Data Source:
HPRD (in vitro)

		PBX1	HOXB1
Description		PBX homeobox 1	homeobox B1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Domain Specific Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Steroid Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Negative Regulation Of Neuron Differentiation Spleen Development Thymus Development Embryonic Skeletal System Development	Regulation Of Transcription, DNA-templated Multicellular Organism Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Height ( 20966902) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Body mass index ( 26426971) Colorectal or endometrial cancer ( 26621817) Primary tooth development (number of teeth) ( 20195514) Waist circumference ( 28552196)
Interacting Genes		23 interacting genes: CREBBP HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	9 interacting genes: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 RCHY1 SERPINA3
Entrez ID		5087	3211
HPRD ID		08889	00855
Ensembl ID		ENSG00000185630	ENSG00000120094
Uniprot IDs		A1MJ41 A8K5V0 P40424 Q53YC7	P14653
PDB IDs		1B72 1PUF	1B72
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?