PAWR and SPSB2

Number of citations of the paper that reports this interaction (PubMedID 20561531)
21

Data Source:
BioGRID (unspecified method)

		PAWR	SPSB2
Description		pro-apoptotic WT1 regulator	splA/ryanodine receptor domain and SOCS box containing 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	Molecular_function Protein Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Colorectal cancer ( 26965516)
Interacting Genes		16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	6 interacting genes: APP DDX4 GALNT15 NOS2 PAWR PRMT1
Entrez ID		5074	84727
HPRD ID		09051	13610
Ensembl ID		ENSG00000177425	ENSG00000111671
Uniprot IDs		Q96IZ0	Q99619
PDB IDs		2JK9	3EMW 5XN3 6DN5 6DN6 6JKJ
Enriched GO Terms of Interacting Partners?
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