CNOT2 and CNOT3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		CNOT2	CNOT3
Description		CCR4-NOT transcription complex subunit 2	CCR4-NOT transcription complex subunit 3
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		8 interacting genes: CNOT1 CNOT3 CNOT4 CNOT8 DDB1 GPS2 NCOR1 NCOR2	8 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3
Entrez ID		4848	4849
HPRD ID		05367	05368
Ensembl ID		ENSG00000111596	ENSG00000088038
Uniprot IDs		A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	A0A024R4R3 O75175
PDB IDs		4C0D 4C0F 5FU6 5FU7	4C0D 4C0G 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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