NFYA and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NFYA	APPBP2
Description		nuclear transcription factor Y subunit alpha	amyloid beta precursor protein binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process	Intracellular Protein Transport Intracellular Transport
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		White blood cell count ( 27863252)	Waist-hip ratio ( 28552196)
Interacting Genes		42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3	81 interacting genes: - AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 CYBA DCD DHRS2 DPEP1 EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 H2AC15 HIPK4 HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		4800	10513
HPRD ID		01793	05616
Ensembl ID		ENSG00000001167	ENSG00000062725
Uniprot IDs		A0A024RD22 P23511	A0A024QZ47 Q92624
PDB IDs		4AWL 6QMP
Enriched GO Terms of Interacting Partners?
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