NFE2 and PEX14

Number of citations of the paper that reports this interaction (PubMedID 11863372)
4

Data Source:
HPRD (in vitro, two hybrid)

		NFE2	PEX14
Description		nuclear factor, erythroid 2	peroxisomal biogenesis factor 14
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Blood Circulation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Ubiquitination Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Chronotype ( 30696823) Mean platelet volume ( 22139419 24026423) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1	10 interacting genes: HDAC1 MED8 MTNR1A NFE2 PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		4778	5195
HPRD ID		09030	03477
Ensembl ID		ENSG00000123405	ENSG00000142655
Uniprot IDs		A8K3E0 Q16621	O75381
PDB IDs		1LVX 2KZ5	2W84 2W85 4BXU
Enriched GO Terms of Interacting Partners?
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