NFATC1 and PPP3R1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NFATC1	PPP3R1
Description		nuclear factor of activated T cells 1	protein phosphatase 3 regulatory subunit B, alpha
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Body Nuclear Transcription Factor Complex	Nucleoplasm Mitochondrion Cytosol Calcineurin Complex Sarcolemma
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Factor Binding Mitogen-activated Protein Kinase P38 Binding	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding
	Biological Process	Cytokine Production Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Transcription By RNA Polymerase II Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Vascular Smooth Muscle Cell Differentiation	Protein Dephosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Pseudoephedrine	Myristic acid Voclosporin
Diseases
GWAS		Blood urea nitrogen levels ( 31152163 29403010) Cerebrospinal P-tau181p levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 31152163 29124443) Creatinine levels ( 31015462 29124443 29403010) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling hurt ( 29500382) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hyperuricemia ( 29124443) Inflammatory bowel disease ( 26192919) Mean platelet volume ( 27863252) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Serum creatinine levels ( 29779033) Working memory ( 31598132)	General cognitive ability ( 29844566) Height ( 25282103) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)
Interacting Genes		16 interacting genes: EGR1 EGR2 EP300 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA RACK1 SPI1 TUBA1A YWHAQ	9 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA
Entrez ID		4772	5534
HPRD ID		02729	03195
Ensembl ID		ENSG00000131196	ENSG00000221823
Uniprot IDs		A8K9C6 B4DER8 F5H4S8 O95644	P63098
PDB IDs		1A66 1NFA 5SVE	1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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