NEU1 and KCNA4

Number of citations of the paper that reports this interaction (PubMedID 10896669)
67

Data Source:
BioGRID (enzymatic study)

		NEU1	KCNA4
Description		neuraminidase 1	potassium voltage-gated channel subfamily A member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axon Dendritic Spine
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Ion Binding
	Biological Process	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Neutrophil Degranulation	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	Voltage gated Potassium channels
Drugs		Oseltamivir	Arginineamide Dalfampridine
Diseases		Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)	Diastolic blood pressure ( 27841878) Luteinizing hormone levels in polycystic ovary syndrome ( 26284813) Menarche (age at onset) ( 27182965) Polycystic ovary syndrome ( 26284813) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878)
Interacting Genes		18 interacting genes: CDC42SE2 CREB3 CTSA EEF1A1 ERRFI1 GLB1 IGF1 JUNB KCNA2 KCNA4 LIG4 LMNA MAF MSH5 NFYA NOTCH4 PBX2 SLC17A2	16 interacting genes: ACTN2 CASK DLG1 DLG2 DLG3 DLG4 DLGAP1 ERBIN KCNA2 LNX1 NDUFA4L2 NEU1 PATJ SAT1 SNTA1 SNTG1
Entrez ID		4758	3739
HPRD ID		09751	01444
Ensembl ID		ENSG00000204386	ENSG00000182255
Uniprot IDs		Q5JQI0 Q99519	P22459
PDB IDs
Enriched GO Terms of Interacting Partners?
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