NEFM and DRD2

Number of citations of the paper that reports this interaction (PubMedID 12122054)
26

Data Source:
BioGRID (two hybrid, pull down)

		NEFM	DRD2
Description		neurofilament medium	dopamine receptor D2
Image		No pdb structure
GO Annotations	Cellular Component	Neurofilament Axon Intermediate Filament Cytoskeleton Neurofibrillary Tangle	Acrosomal Vesicle Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Postsynaptic Density Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Dendritic Spine Perikaryon Axon Terminus Ciliary Membrane Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adrenergic Receptor Activity Protein Binding Drug Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Neurofilament Bundle Assembly	Temperature Homeostasis Response To Hypoxia Negative Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Response To Amphetamine Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Autophagy G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell-cell Signaling Neuron-neuron Synaptic Transmission Axonogenesis Synapse Assembly Sensory Perception Of Smell Behavior Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Protein Localization Negative Regulation Of Cell Proliferation Associative Learning Visual Learning Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Auditory Behavior Activation Of Protein Kinase Activity Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Response To Drug Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Pigmentation Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Glial Cell-derived Neurotrophic Factor Secretion Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways			Dopamine receptors
Drugs			Amphetamine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Doxepin Desipramine Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine Pimavanserin BL-1020 ACP-104 Cariprazine Lumateperone Sertindole Mianserin Asenapine Amisulpride Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Pardoprunox Tetrahydropalmatine Piribedil Raclopride Tiapride
Diseases
GWAS		Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder ( 30940813) Alcoholic chronic pancreatitis ( 28754779) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 27089181 29255261) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 28991256 25056061 29483656 30285260) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531)
Interacting Genes		10 interacting genes: APOE DISC1 DRD2 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK	26 interacting genes: ADORA2A CADPS CADPS2 CALM1 CLIC6 EPB41 EPB41L1 FLNA GIPC1 GNAI2 GNAI3 GNAZ GNB5 GRIA2 KCNJ6 KCNJ9 NCS1 NEFM NSF PAWR PPP1R9B SLC6A3 SSTR2 SSTR5 TRPC4 TRPC5
Entrez ID		4741	1813
HPRD ID		01205	00539
Ensembl ID		ENSG00000104722	ENSG00000149295
Uniprot IDs		P07197 Q9UK51	A0A024R3C5 A0A024R3I6 P14416
PDB IDs			1I15 5AER 6CM4
Enriched GO Terms of Interacting Partners?
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