MSH3 and HUS1

Number of citations of the paper that reports this interaction (PubMedID 20188637)
12

Data Source:
BioGRID (affinity chromatography technology, far western blotting)

		MSH3	HUS1
Description		mutS homolog 3	HUS1 checkpoint clamp component
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Binding Protein Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Colorectal cancer
GWAS		HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124)	Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		13 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 TSC22D2 XPA	23 interacting genes: CD200 DNAJC7 FEN1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		4437	3364
HPRD ID		02931	04787
Ensembl ID		ENSG00000113318	ENSG00000136273
Uniprot IDs		P20585	A4D2F2 O60921
PDB IDs		3THW 3THX 3THY 3THZ	3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?
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