GET3 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GET3	ASPH
Description		guided entry of tail-anchored proteins factor 3, ATPase	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Peptide-aspartate Beta-dioxygenase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Muscle Contraction Pattern Specification Process Negative Regulation Of Cell Proliferation Electron Transport Chain Regulation Of Protein Stability Ion Transmembrane Transport Limb Morphogenesis Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Roof Of Mouth Development Face Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Depolymerization Regulation Of Cardiac Conduction
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Stimuli-sensing channels Ion homeostasis
Drugs		ATP	L-Aspartic Acid Succinic acid
Diseases
GWAS			Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Urate levels in overweight individuals ( 25811787)
Interacting Genes		14 interacting genes: APLN ASPH CACNA1A GET4 GPX7 HILPDA PFDN1 SEC61A1 SEC61B STATH STX5 TK1 TTR VAMP2	5 interacting genes: APP FBXO7 GET3 RAB2A TRDN
Entrez ID		439	444
HPRD ID		03555	08996
Ensembl ID		ENSG00000198356	ENSG00000198363
Uniprot IDs		O43681	B4DQ07 B7ZM96 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6RK9
Enriched GO Terms of Interacting Partners?
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