MITF and EBP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MITF	EBP
Description		melanocyte inducing transcription factor	EBP cholestenol delta-isomerase
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Dimerization Activity E-box Binding	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Transmembrane Signaling Receptor Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Cholestenol Delta-isomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of RNA Biosynthetic Process	Skeletal System Development Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Xenobiotic Transport
Pathways		SUMOylation of transcription factors	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs			Tamoxifen
Diseases		Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS) Malignant melanoma
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 27863252) Severe influenza A (H1N1) infection ( 26379185) Systolic blood pressure ( 27841878)
Interacting Genes		29 interacting genes: APP CTNNB1 EBP EP300 FBXO7 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	8 interacting genes: APP CREB3 EBPL ESRRG GLP1R MITF MTNR1B RAB1A
Entrez ID		4286	10682
HPRD ID		01138	02192
Ensembl ID		ENSG00000187098	ENSG00000147155
Uniprot IDs		A0A087WXU1 B4DNC7 O75030 Q8WYR3	A0A024QYX0 Q15125
PDB IDs		4C7N	6OHT 6OHU
Enriched GO Terms of Interacting Partners?
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