MCM7 and NAB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MCM7	NAB2
Description		minichromosome maintenance complex component 7	NGFI-A binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex	Nucleus
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Endochondral Ossification Regulation Of Transcription, DNA-templated Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Positive Regulation Of Tau-protein Kinase Activity
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)
Interacting Genes		72 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 UBE3A UBQLN1 USHBP1	34 interacting genes: CCDC33 CCHCR1 CWF19L2 DGCR6 EGR1 EGR2 GCC1 JAKMIP2 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA MAPK3 MCM7 MDFI MORF4L1 NEDD9 NME7 NOTCH2NLA PHF1 PHOSPHO2 PIN1 RBPMS RFC5 SCNM1 SUMO1P1 TCEANC TCHP TGIF2LY TLE5 TTC19 ZBED8 ZMYND19
Entrez ID		4176	4665
HPRD ID		01154	03854
Ensembl ID		ENSG00000166508	ENSG00000166886
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	Q15742
PDB IDs
Enriched GO Terms of Interacting Partners?
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