MBL2 and CALCR

Number of citations of the paper that reports this interaction (PubMedID 11560994)
259

Data Source:
HPRD (in vivo)

		MBL2	CALCR
Description		mannose binding lectin 2	calcitonin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Extracellular Matrix Collagen-containing Extracellular Matrix	Cell Plasma Membrane Integral Component Of Plasma Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3
	Molecular Function	Signaling Receptor Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Calcitonin Receptor Activity Protein Binding Calcitonin Binding Amylin Receptor Activity
	Biological Process	Complement Activation, Lectin Pathway Growth Plate Cartilage Chondrocyte Morphogenesis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of Cell Death Positive Regulation Of Peptidyl-serine Phosphorylation Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Response To Glucocorticoid Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Amylin Receptor Signaling Pathway Response To Amyloid-beta Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Lectin pathway of complement activation Initial triggering of complement	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside O4-Sulfonylgalactose beta-L-methyl-fucose N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine	Salmon Calcitonin Pramlintide
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency Tuberculosis
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25760438 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Weight ( 28552196)
Interacting Genes		8 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC	9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1
Entrez ID		4153	799
HPRD ID		01107	00239
Ensembl ID		ENSG00000165471	ENSG00000004948
Uniprot IDs		P11226	A0A0A0MRG0 A0A0C4DG16 P30988
PDB IDs		1HUP	5II0 5UZ7 6NIY
Enriched GO Terms of Interacting Partners?
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