SMAD6 and RUNX2

Number of citations of the paper that reports this interaction (PubMedID 16299379)
49

Data Source:
HPRD (in vitro)

		SMAD6	RUNX2
Description		SMAD family member 6	RUNX family transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding
	Biological Process	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Hemopoiesis Neuron Differentiation T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Signaling by BMP RUNX2 regulates bone development
Drugs
Diseases			Cleidocranial dysplasia
GWAS		Asthma ( 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Height ( 31562340) Lung cancer (smoking interaction) ( 24658283) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Central corneal thickness ( 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) facial morphology traits (multivariate analysis) ( 27193062) Height ( 25429064 18391951) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Survival in pancreatic cancer ( 28470677)
Interacting Genes		16 interacting genes: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	38 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRIM2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1
Entrez ID		4091	860
HPRD ID		04240	02566
Ensembl ID		ENSG00000137834	ENSG00000124813
Uniprot IDs		O43541	A0A0D9SEN7 Q13950 Q32MY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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