SH2D1A and SLAMF6

Number of citations of the paper that reports this interaction (PubMedID 11489943)
68

Data Source:
HPRD (in vitro, in vivo)

		SH2D1A	SLAMF6
Description		SH2 domain containing 1A	SLAM family member 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response T-helper 17 Cell Lineage Commitment
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Blood protein levels ( 30072576 29875488) Graves' disease ( 23612905) Multiple sclerosis ( 24076602)
Interacting Genes		26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	4 interacting genes: PTPN11 PTPN6 SH2D1A ZAP70
Entrez ID		4068	114836
HPRD ID		02390	05920
Ensembl ID		ENSG00000183918	ENSG00000162739
Uniprot IDs		O60880	B4E1U5 Q96DU3
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2IF7
Enriched GO Terms of Interacting Partners?
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