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LRP5 and AXIN1
Number of citations of the paper that reports this interaction (PubMedID
11336703
)
244
Data Source:
HPRD
(in vivo)
LRP5
AXIN1
Description
LDL receptor related protein 5
axin 1
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Wnt-Frizzled-LRP5/6 Complex
Wnt Signalosome
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Molecular Function
Protein Binding
Coreceptor Activity
Wnt-protein Binding
Toxin Transmembrane Transporter Activity
Wnt-activated Receptor Activity
Coreceptor Activity Involved In Wnt Signaling Pathway
Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
Biological Process
Gastrulation With Mouth Forming Second
Positive Regulation Of Mesenchymal Cell Proliferation
Osteoblast Development
Glucose Catabolic Process
Endocytosis
Cholesterol Metabolic Process
Regulation Of Blood Pressure
Positive Regulation Of Cell Proliferation
Response To Radiation
Anterior/posterior Pattern Specification
Positive Regulation Of Osteoblast Proliferation
Somatic Stem Cell Population Maintenance
Extracellular Matrix-cell Signaling
Cell Migration Involved In Gastrulation
Cholesterol Homeostasis
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Bone Remodeling
Bone Marrow Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Anatomical Structure Regression
Retina Morphogenesis In Camera-type Eye
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Adipose Tissue Development
Cell-cell Signaling Involved In Mammary Gland Development
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Retinal Blood Vessel Morphogenesis
Negative Regulation Of Protein Serine/threonine Kinase Activity
Toxin Transport
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNF mutants show enhanced WNT signaling and proliferation
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
1,4-Dithiothreitol
Diseases
Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
Osteoporosis-pseudoglioma syndrome (OPPG)
Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1)
Hepatocellular carcinoma
Caudal duplication anomaly
GWAS
Bone mineral density (
24249740
18455228
)
Bone mineral density (paediatric, skull) (
24945404
)
Bone mineral density (paediatric, total body less head) (
28743860
)
Bone mineral density (spine) (
19801982
)
Femoral neck bone mineral density (
29499414
)
Femoral neck section modulus (
30888730
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
Lumbar spine bone mineral density (
29499414
22504420
)
Medication use (drugs affecting bone structure and mineralization) (
31015401
)
Monobrow (
27182965
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular hemoglobin concentration (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Interacting Genes
9 interacting genes:
AXIN1
CAPRIN2
DKK1
FZD8
MESD
MTDH
SMAD9
THBS1
WNT1
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
UTP14A
ZBTB26
ZFYVE19
Entrez ID
4041
8312
HPRD ID
04616
04819
Ensembl ID
ENSG00000162337
ENSG00000103126
Uniprot IDs
O75197
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
Enriched GO Terms of Interacting Partners
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