LMO1 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LMO1	RBBP8
Description		LIM domain only 1	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcriptional Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding RNA Polymerase II Repressing Transcription Factor Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding Flap-structured DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Hatching DNA Replication DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Estradiol Cell Division Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination
Drugs
Diseases			Seckel syndrome
GWAS		Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Height ( 31562340) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)	Eosinophil percentage of white cells ( 27863252) Height ( 25429064 18391951) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Scalp hair shape ( 26926045) Tuberculosis ( 20694014)
Interacting Genes		39 interacting genes: ADAMTSL4 BCL11A BLZF1 CARD9 CBY2 CDCA7L CDX4 CEP170P1 CEP44 ERBIN GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NAGK NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SAXO1 SNTA1 SOX5 TAL1 TAL2 TASOR2 TCF4 TFIP11 TLE5 TRIM27 ZBTB43 ZNF219	37 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4
Entrez ID		4004	5932
HPRD ID		01738	04990
Ensembl ID		ENSG00000166407	ENSG00000101773
Uniprot IDs		E9PK83 P25800	A0A024RC34 Q99708
PDB IDs			2L4Z 4D2H
Enriched GO Terms of Interacting Partners?
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