LIMK1 and PAK6

Number of citations of the paper that reports this interaction (PubMedID 26375402)
14

Data Source:
BioGRID (enzymatic study)

		LIMK1	PAK6
Description		LIM domain kinase 1	p21 (RAC1) activated kinase 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Neuron Projection	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly	Regulation Of Transcription, DNA-templated Apoptotic Process Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs	Activation of RAC1
Drugs		Dabrafenib
Diseases
GWAS		Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		29 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SELENOS SRPK1 SSH3 YWHAZ	18 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ SEMA3B SNX2 TPD52L1
Entrez ID		3984	56924
HPRD ID		03210	06426
Ensembl ID		ENSG00000106683	ENSG00000137843
Uniprot IDs		P53667	A0A024R9Q4 Q9NQU5
PDB IDs		3S95 5HVJ 5HVK 5L6W 5NXC	2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?
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