LHCGR and TSHR

Number of citations of the paper that reports this interaction (PubMedID 1651314)
6

Data Source:
HPRD (in vitro)

		LHCGR	TSHR
Description		luteinizing hormone/choriogonadotropin receptor	thyroid stimulating hormone receptor
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GO Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Male Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Cognition Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)	Thyrotropin Alfa
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP)	Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Body mass index ( 28892062) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Visceral fat ( 22589738)
Interacting Genes		11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR	23 interacting genes: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB
Entrez ID		3973	7253
HPRD ID		01073	04537
Ensembl ID		ENSG00000138039	ENSG00000165409
Uniprot IDs		P22888	A0A0A0MTJ0 P16473
PDB IDs		1LUT 1XUL	1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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