LGALS2 and LTA

Number of citations of the paper that reports this interaction (PubMedID 15129282)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		LGALS2	LTA
Description		galectin 2	lymphotoxin alpha
Image
GO Annotations	Cellular Component		Extracellular Space Plasma Membrane
	Molecular Function	Protein Binding Galactoside Binding Carbohydrate Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process		Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation
Pathways			TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Beta-D-Glucose	Etanercept
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Response to anti-depressant treatment in major depressive disorder ( 22041458)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)
Interacting Genes		6 interacting genes: APP IKBKG LTA SDCBP SDCBP2 TUBA4A	10 interacting genes: CREB3 LGALS2 LTB LTBR SLC30A2 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD
Entrez ID		3957	4049
HPRD ID		08859	01084
Ensembl ID		ENSG00000100079	ENSG00000226979
Uniprot IDs		P05162	P01374 Q5STV3
PDB IDs		1HLC 5DG1 5DG2 5EWS	1TNR 4MXV 4MXW
Enriched GO Terms of Interacting Partners?
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