LDLR and AP1M2

Number of citations of the paper that reports this interaction (PubMedID 11157985)
113

Data Source:
HPRD (in vivo, in vitro)

		LDLR	AP1M2
Description		low density lipoprotein receptor	adaptor related protein complex 1 subunit mu 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Endolysosome Membrane Somatodendritic Compartment Receptor Complex Apical Part Of Cell Sorting Endosome PCSK9-LDLR Complex	Golgi Membrane Cell Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Protease Binding Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding Identical Protein Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Long-term Memory Cholesterol Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Intestinal Cholesterol Absorption Cholesterol Transport Plasma Lipoprotein Particle Clearance Chylomicron Remnant Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Lipoprotein Catabolic Process Cholesterol Homeostasis Viral Entry Into Host Cell Artery Morphogenesis Positive Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Membrane Organization Response To Caloric Restriction Negative Regulation Of Astrocyte Activation Cholesterol Import Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Cholesterol Metabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Negative Regulation Of Microglial Cell Activation Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Amyloid Fibril Formation	Protein Targeting Vesicle Targeting Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance Chylomicron clearance LDL clearance Retinoid metabolism and transport	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		Porfimer sodium
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Abdominal aortic aneurysm ( 27899403 24046328) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 29212778 24262325 30104761 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortisol levels (saliva) ( 28843169) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 29531354) LDL cholesterol ( 23726366 24097068 18193043 18193044 20864672 19060906 19060910 19060911 30275531 21347282 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Low density lipoprotein cholesterol levels ( 30911093 29403010 31217584) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109 23823483 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Peripheral artery disease ( 31285632) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Stroke ( 29531354) Total cholesterol levels ( 28334899 30911093 29403010 31217584)	Bipolar disorder ( 31043756) Lymphocyte percentage of white cells ( 27863252) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 27863252 28957414)
Interacting Genes		14 interacting genes: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 PCSK9 PF4 SNX17	20 interacting genes: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2
Entrez ID		3949	10053
HPRD ID		06091	06296
Ensembl ID		ENSG00000130164	ENSG00000129354
Uniprot IDs		A0A024R7D5 P01130	Q53GI5 Q9Y6Q5
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2MG9 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9 5OY9 5OYL
Enriched GO Terms of Interacting Partners?
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