LBR and CBX5

Number of citations of the paper that reports this interaction (PubMedID 8663349)
125

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		LBR	CBX5
Description		lamin B receptor	chromobox 5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Histone Deacetylase Complex Kinetochore Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs			Copper
Diseases		HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Delirium ( 29631748)	Alcohol consumption ( 31358974) Blood protein levels ( 30072576) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AKAP8L CBX3 CBX5 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG	55 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1
Entrez ID		3930	23468
HPRD ID		02488	05131
Ensembl ID		ENSG00000143815	ENSG00000094916
Uniprot IDs		Q14739	P45973 V9HWG0
PDB IDs		2DIG	3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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