INCA1 and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		INCA1	UBE2D4
Description		inhibitor of CDK, cyclin A1 interacting protein 1	ubiquitin conjugating enzyme E2 D4 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Ubiquitin Ligase Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)
Interacting Genes		39 interacting genes: ARMC7 CABP5 CCNA1 CDC23 CDK2 CDKN2D CHCHD2 COL8A1 CTNNBIP1 DAZAP2 DMRT3 DPH7 EPHB6 FHL2 FMR1 GRB2 HAUS1 NEK6 OSGIN1 PATE1 PTGER3 RAB5C RAMAC RBPMS RNF26 SAP18 SCNM1 SEC14L4 SPG21 SPOUT1 STAMBPL1 STK16 TRIM26 TRIP6 UBE2D4 UBXN2B VPS28 ZMYND19 ZNF205-AS1	99 interacting genes: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 ITCH LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 PRKN RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBA1 UBC UBE4A UBOX5 UBTD1 UFM1 UHRF2 UVSSA XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		388324	51619
HPRD ID		17150	14242
Ensembl ID		ENSG00000196388	ENSG00000078967
Uniprot IDs		Q0VD86	A0A024RA90 Q9UQL0 Q9Y2X8
PDB IDs
Enriched GO Terms of Interacting Partners?
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