KCNJ12 and LIN7C

Number of citations of the paper that reports this interaction (PubMedID 15024025)
60

Data Source:
HPRD (in vitro, in vivo)

		KCNJ12	LIN7C
Description		potassium inwardly rectifying channel subfamily J member 12	lin-7 homolog C, crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Dofetilide Yohimbine
Diseases
GWAS		Body mass index ( 28892062 25673413) Height ( 20881960 31562340) Waist-hip ratio ( 25673412)	Bone mineral density (paediatric, skull) ( 24945404) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		16 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	5 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12
Entrez ID		3768	55327
HPRD ID		09083	17279
Ensembl ID		ENSG00000184185	ENSG00000148943
Uniprot IDs		Q14500	Q9NUP9
PDB IDs			3LRA
Enriched GO Terms of Interacting Partners?
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