ARF1 and MDM4

Number of citations of the paper that reports this interaction (PubMedID 11297540)
21

Data Source:
HPRD (in vitro, in vivo)

		ARF1	MDM4
Description		ADP ribosylation factor 1	MDM4 regulator of p53
Image
GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Late Endosome Peroxisomal Membrane Trans-Golgi Network Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere COPI-coated Vesicle Cell Leading Edge Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Phospholipase D Activator Activity	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Regulation Of Receptor Internalization Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Intracellular Protein Transport Actin Filament Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Very-low-density Lipoprotein Particle Assembly Interleukin-12-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Endocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Defense Response To Virus By Virus Positive Regulation Of Protein Secretion Golgi To Transport Vesicle Transport Long-term Synaptic Depression Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Budding Dendritic Spine Organization Lysosomal Membrane Organization Cellular Response To Virus Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Phospholipid Metabolic Process Mitotic Cleavage Furrow Ingression	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein Stabilization Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs		1,3-Propandiol Guanosine-3'-Monophosphate-5'-Diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Glycerin
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091)	Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452)
Interacting Genes		45 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 EEF1G GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 TMED10 TMED2 TMEM106A WBP11	58 interacting genes: AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN4
Entrez ID		375	4194
HPRD ID		00054	04082
Ensembl ID		ENSG00000143761	ENSG00000198625
Uniprot IDs		A0A024R3Q0 P84077	A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE	2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y
Enriched GO Terms of Interacting Partners?
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