KARS1 and SLC25A6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KARS1	SLC25A6
Description		lysyl-tRNA synthetase 1	solute carrier family 25 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Integral Component Of Membrane
	Molecular Function	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity	ATP:ADP Antiporter Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity	Protein Targeting To Mitochondrion Apoptotic Process ADP Transport ATP Transport Viral Process Regulation Of Insulin Secretion Transmembrane Transport
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Mitochondrial protein import Mitochondrial protein import Influenza Virus Induced Apoptosis Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs		L-Lysine	Clodronic Acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM	19 interacting genes: AP2B1 CHEK2 CHGB FGFR3 KARS1 KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NLA PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM
Entrez ID		3735	293
HPRD ID		03249	02461
Ensembl ID		ENSG00000065427	ENSG00000169100
Uniprot IDs		Q15046	P12236 Q6I9V5
PDB IDs		3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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