ARAF and RRAS

Number of citations of the paper that reports this interaction (PubMedID 10848612)
12

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vitro)

		ARAF	RRAS
Description		A-Raf proto-oncogene, serine/threonine kinase	RAS related
Image
GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Plasma Membrane Focal Adhesion Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	MAPK Cascade Cellular Protein Modification Process Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs		ATP
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)
Interacting Genes		59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG YWHAZ	15 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1
Entrez ID		369	6237
HPRD ID		02405	01299
Ensembl ID		ENSG00000078061	ENSG00000126458
Uniprot IDs		A0A024R178 P10398 Q96II5	A0A024QZF2 P10301
PDB IDs		1WXM 2MSE	2FN4
Enriched GO Terms of Interacting Partners?
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