ITGAM and ICAM4

Number of citations of the paper that reports this interaction (PubMedID 10846180)
13

Data Source:
HPRD (in vivo)

		ITGAM	ICAM4
Description		integrin subunit alpha M	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Protein Binding Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Integrin Binding
	Biological Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Forebrain Development Positive Regulation Of Superoxide Anion Generation Toll-like Receptor 4 Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Leukocyte Migration Positive Regulation Of Protein Targeting To Membrane Apoptotic Signaling Pathway Amyloid-beta Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Hippocampal Neuron Apoptotic Process Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Prostaglandin-E Synthase Activity	Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26502338 18204098 21408207 19165918 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Blood protein levels ( 30072576 28240269)
Interacting Genes		19 interacting genes: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 LMNA PLAUR SHARPIN THY1	10 interacting genes: AKAP8L CREB3 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NLA RHAG
Entrez ID		3684	3386
HPRD ID		00411	00198
Ensembl ID		ENSG00000169896	ENSG00000105371
Uniprot IDs		P11215	Q14773 U5U6P8
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2
Enriched GO Terms of Interacting Partners?
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