AR and IDE

Number of citations of the paper that reports this interaction (PubMedID 8051160)
10

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		AR	IDE
Description		androgen receptor	insulin degrading enzyme
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Protein-containing Complex	Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Basal Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Androgen Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Transcription Regulatory Region DNA Binding ATPase Binding POU Domain Binding	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Systemic Arterial Blood Pressure Epithelial Cell Morphogenesis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Spermatogenesis Single Fertilization Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Protein Deubiquitination Male Somatic Sex Determination Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Leydig Cell Differentiation Multicellular Organism Growth Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Developmental Growth Animal Organ Formation Male Genitalia Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Prostate Induction By Androgen Receptor Signaling Pathway Morphogenesis Of An Epithelial Fold Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Testosterone Stimulus Seminiferous Tubule Development Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation	Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import
Drugs		Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Flutamide Oxandrolone Fluphenazine Testosterone Mitotane Estrone Nilutamide Tamoxifen Fludrocortisone Drostanolone Norgestimate Nandrolone phenpropionate Ketoconazole Acetophenazine Bicalutamide Fluoxymesterone Drospirenone Danazol Testosterone Propionate Oxybenzone Delta1-dihydrotestosterone Boldenone Calusterone Propericiazine Prasterone Flufenamic Acid Dihydrotestosterone (R)-Bicalutamide Methyltrienolone (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Cyproterone acetate LGD2941 Oxymetholone Methyltestosterone Norelgestromin 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL Triclosan Nandrolone decanoate Ulipristal Enzalutamide Eugenol Dienogest Norgestrel Homosalate Enzacamene Esculin	Insulin Human Insulin Pork Bacitracin
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism Prostate cancer Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
GWAS		Balding ( 26926045) Excessive daytime sleepiness ( 27992416) LDL cholesterol ( 19060910) Male-pattern baldness ( 29146897 22693459 27182965 22032556 18849991 28196072) Prostate cancer ( 21743467)	Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		219 interacting genes: ACTB AHR AKT1 APOL2 APPBP2 ARID5A ATF2 BAG1 BRCA1 CACUL1 CALM1 CALR CASP1 CASP3 CASP7 CASP8 CAV1 CCAR2 CCND1 CCNE1 CCNH CDC25A CDC25B CDC37 CDK1 CDK6 CDK7 CDK9 CEBPA CEBPB CHD8 COX5B CREBBP CTDSP2 CTNNB1 CUL4B DAP3 DAXX DCAF6 DCC DDB2 DDC DENND5A EFCAB6 EGFR ELF3 EP300 ERCC2 ERCC3 ESR1 ETV5 FHL2 FLNA FOXA1 FOXG1 FOXO1 GADD45GIP1 GAK GAPDH GLI2 GRIP1 GSK3B GSN GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 HDAC1 HDAC3 HDAC4 HIF1A HIPK3 HMGB1 HMGB2 HOTAIR HSP90AA1 IARS1 IDE IFI16 IL6ST JMJD1C JUN KAT2B KAT5 KAT7 KDM1A KIF1A KIFAP3 KLK2 LCOR MAGEA11 MAPK1 MDM2 MDN1 MED1 MED12L MED14 MED24 MLH3 MYBBP1A MYLIP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NDE1 NELFCD NFKB1 NISCH NLRP10 NONO NR0B1 NR0B2 NR2C1 NR2C2 NR3C1 NR3C2 NR5A1 NRIP1 NSD1 NSD2 PA2G4 PAK6 PELP1 PIAS1 PIAS2 PIAS3 PIAS4 PNRC1 PNRC2 POU2F1 POU2F2 POU5F1 PRKG1 PRMT1 PRPF6 PSMC3IP PTEN PXN RAC3 RACK1 RAD54L2 RAD9A RAF1 RAN RANBP9 RB1 RBAK RCHY1 REL RELA REPS2 RNASEL RNF14 RNF4 RNF6 RUNX1 RUNX2 SART3 SFPQ SH3YL1 SIRT1 SLC25A4 SMAD1 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCE1 SP1 SPDEF SPOP SRC SREBF1 SRY STAT3 STUB1 SUMO1 SUV39H2 SVIL TADA3 TAF1 TBP TCF20 TCF4 TCF7L2 TDG TGFB1I1 TGIF1 TLE5 TMF1 TNK2 TPD52 TRIM24 TRIP4 TSG101 TXNDC5 UBE2I UBE3A USP10 UXT VCP VHL WIPI1 XRCC5 XRCC6 YWHAQ ZBTB1 ZBTB16 ZBTB32 ZBTB7A ZMIZ1 ZMIZ2 ZNF451	12 interacting genes: APP AR BRDT IGF1 IGF2 INS NR3C1 PEX5 SLC28A2 SORCS3 UBC UCHL5
Entrez ID		367	3416
HPRD ID		02437	00894
Ensembl ID		ENSG00000169083	ENSG00000119912
Uniprot IDs		A0A087WUX9 F1D8N5 G4VV16 P10275 Q9NUA2	A0A3B3ISG5 B3KSB8 P14735
PDB IDs		1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 2Z4J 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW 4K7A 4OEA 4OED 4OEY 4OEZ 4OFR 4OFU 4OGH 4OH5 4OH6 4OHA 4OIL 4OIU 4OJ9 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM 4QL8 5CJ6 5JJM 5T8E 5T8J 5V8Q 5VO4	2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
Enriched GO Terms of Interacting Partners?
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