IRF5 and ALPI

Number of citations of the paper that reports this interaction (PubMedID 19786094)
12

Data Source:
BioGRID (pull down)

		IRF5	ALPI
Description		interferon regulatory factor 5	alkaline phosphatase, intestinal
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Cytosol	Extracellular Region Plasma Membrane Anchored Component Of Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Magnesium Ion Binding Protease Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding
	Biological Process	Immune System Process Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Phosphatidic Acid Biosynthetic Process Digestion Dephosphorylation
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	Synthesis of PA Post-translational modification: synthesis of GPI-anchored proteins Digestion
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Primary biliary cholangitis ( 21399635 20639880 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 21156761 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26663301 23053960 26502338 18204098 21408207 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 21750679 31672989 20383147 30247649 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 28067908 26398853 23128233 21297633)	Hepcidin/ferritin ratio ( 27846281)
Interacting Genes		17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1	8 interacting genes: BICD1 HSPB1 IRF5 KRTAP10-3 KRTAP10-8 KRTAP10-9 NOD2 NOTCH2NLA
Entrez ID		3663	248
HPRD ID		06240	01376
Ensembl ID		ENSG00000128604	ENSG00000163295
Uniprot IDs		A0A0G2USB5 B7Z1M2 C9JAU6 Q13568	A0A024R4A2 P09923
PDB IDs		3DSH
Enriched GO Terms of Interacting Partners?
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