INCENP and CDCA8

Number of citations of the paper that reports this interaction (PubMedID 15249581)
142

Data Source:
HPRD (in vivo, in vitro)

		INCENP	CDCA8
Description		inner centromere protein	cell division cycle associated 8
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome Lateral Element Central Element Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone	Chromosome, Centromeric Region Cell Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding Protein Serine/threonine Kinase Activator Activity	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cytokinesis Chromosome Segregation Meiotic Chromosome Condensation Histone Phosphorylation Meiotic Spindle Midzone Assembly Metaphase Plate Congression Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cytokinesis	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine
Diseases
GWAS		Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		11 interacting genes: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14 MARK2	14 interacting genes: AURKB BIRC5 H3C14 HLA-DRB3 INCENP MAPKAPK5 NEK3 PIAS2 RANBP2 SENP3 SGO1 SGO2 TTK UBE2I
Entrez ID		3619	55143
HPRD ID		05103	13017
Ensembl ID		ENSG00000149503	ENSG00000134690
Uniprot IDs		Q9NQS7	Q53HL2
PDB IDs		2QFA 4AF3 5IEH 5IEK 6GR8 6GR9	2KDD 2QFA 2RAW 2RAX
Enriched GO Terms of Interacting Partners?
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