IL15 and IL15RA

Number of citations of the paper that reports this interaction (PubMedID 7641685)
134

Data Source:
HPRD (in vitro, in vivo)

		IL15	IL15RA
Description		interleukin 15	interleukin 15 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Cell Surface Nuclear Speck	Golgi Membrane Extracellular Space Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Cellular Response To Vitamin D Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein O-linked Glycosylation	Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Interleukin-15 signaling Interleukin-15 signaling	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Cefazolin
Diseases
GWAS		Insomnia ( 29520036) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Soluble interleukin-2 receptor subunit alpha ( 26293465)
Interacting Genes		7 interacting genes: APP IL15RA IL2RB IL2RG STAT5B TRAF3 ZNRD1	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		3600	3601
HPRD ID		02776	03045
Ensembl ID		ENSG00000164136	ENSG00000134470
Uniprot IDs		P40933	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?
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