IL13RA1 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 8910586)
49

Data Source:
HPRD (in vivo, in vitro)

		IL13RA1	IL4R
Description		interleukin 13 receptor subunit alpha 1	interleukin 4 receptor
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GO Annotations	Cellular Component	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Receptor Complex	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases			Asthma
GWAS		Body mass index ( 28892062) Type 2 diabetes ( 30718926)	Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: DLG4 IL13 IL4R TMEM39B TRAF3IP1 TYK2	22 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3597	3566
HPRD ID		02125	00990
Ensembl ID		ENSG00000131724	ENSG00000077238
Uniprot IDs		P78552	B2RBY1 P24394
PDB IDs		3BPN 3BPO 4HWB 5E4E	1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL
Enriched GO Terms of Interacting Partners?
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