CXCL8 and IL12A

Number of citations of the paper that reports this interaction (PubMedID 16862120)
134

Data Source:
HPRD (in vitro)

		CXCL8	IL12A
Description		C-X-C motif chemokine ligand 8	interleukin 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Late Endosome Lumen Interleukin-12 Complex
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Immune Response Cell Cycle Arrest Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Leukocyte Chemotaxis Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Cell Proliferation Response To Virus Response To UV-B Viral Process Cell Migration Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process T-helper 1 Cell Activation Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Interleukin-35-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs		ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS			Behcet's disease ( 23291587 27548383 25799145) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 18311140) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 24076602 19525953 21833088) Primary biliary cholangitis ( 28425483 19458352 21399635 20639880 26394269 28062665) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic sclerosis ( 24387989 31672989)
Interacting Genes		18 interacting genes: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	5 interacting genes: CD28 CXCL8 EBI3 IL12B WASF1
Entrez ID		3576	3592
HPRD ID		00909	01193
Ensembl ID		ENSG00000169429	ENSG00000168811
Uniprot IDs		A0A024RDA5 P10145	O60595 P29459
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6N2U	1F45 3HMX
Enriched GO Terms of Interacting Partners?
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