JCHAIN and CD79A

Number of citations of the paper that reports this interaction (PubMedID 1292512)
6

Data Source:
HPRD (in vivo)

		JCHAIN	CD79A
Description		joining chain of multimeric IgA and IgM	CD79a molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft
	Molecular Function	Single-stranded DNA Binding Antigen Binding IgA Binding Protein Binding, Bridging Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Retina Homeostasis Adaptive Immune Response Glomerular Filtration Receptor-mediated Endocytosis Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Leukocyte Migration Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly	Adaptive Immune Response B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Scavenging of heme from plasma	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Zinc
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		2 interacting genes: CD79A IGHM	17 interacting genes: BLK BLNK CD19 CD5 CD79B FANCA FATE1 FCAR FYN HCLS1 IGHM JCHAIN LCK LYN PIGR PTPN6 SYK
Entrez ID		3512	973
HPRD ID		00991	00203
Ensembl ID		ENSG00000132465	ENSG00000105369
Uniprot IDs		P01591	P11912
PDB IDs			1CV9
Enriched GO Terms of Interacting Partners?
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