IGFBP3 and GPI

Number of citations of the paper that reports this interaction (PubMedID 15059907)
7

Data Source:
HPRD (in vitro)

		IGFBP3	GPI
Description		insulin like growth factor binding protein 3	glucose-6-phosphate isomerase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Carbohydrate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Positive Regulation Of Endothelial Cell Migration Neutrophil Degranulation Positive Regulation Of Immunoglobulin Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Alitretinoin Mecasermin	alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-Phospho-D-Arabinohydroxamic Acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate Erythose-4-Phosphate Fructose-6-Phosphate Copper Artenimol
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256)
Interacting Genes		29 interacting genes: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RXRA TF	5 interacting genes: AMFR CSNK2A1 IGFBP3 PARP14 PCNA
Entrez ID		3486	2821
HPRD ID		00899	01394
Ensembl ID		ENSG00000146674	ENSG00000105220
Uniprot IDs		B3KPF0 P17936	A0A2U3TZU2 B4DE36 P06744
PDB IDs			1IAT 1IRI 1JIQ 1JLH 1NUH
Enriched GO Terms of Interacting Partners?
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