IGF1 and IGFBP5

Number of citations of the paper that reports this interaction (PubMedID 9497324)
32

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		IGF1	IGFBP5
Description		insulin like growth factor 1	insulin like growth factor binding protein 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin-like Growth Factor Ternary Complex Exocytic Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Activation Of MAPK Activity Skeletal System Development Cell Activation Platelet Degranulation Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Cell Proliferation Positive Regulation Of Cell Proliferation Response To Heat Glycolate Metabolic Process Regulation Of Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Proteoglycan Biosynthetic Process Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Smooth Muscle Cell Apoptotic Process Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Protein Kinase B Signaling Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Myoblast Proliferation Negative Regulation Of Oocyte Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Trophectodermal Cell Proliferation Cellular Response To Amyloid-beta Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		N,N-bis(3-(D-gluconamido)propyl)deoxycholamide N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases		Malignant pleural mesothelioma Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Birth weight ( 31043758 27680694) Dental caries (decayed and filled deciduous teeth) ( 31533690) Fasting blood insulin ( 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Height ( 25429064 19893584 31562340 31217584 20189936) Homeostasis model assessment of insulin resistance ( 20081858) Intraocular pressure ( 29617998 29785010) Lung function (FVC) ( 30804560) Mammographic density (dense area) ( 25342443) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Response to quetiapine in schizophrenia ( 29503163) Systolic blood pressure ( 30224653) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Interacting Genes		18 interacting genes: CCN3 CCN5 CTSB E2F1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 NEU1 SOX4 TF	21 interacting genes: ADAM12 BAG6 CREB3 CSDE1 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 LMNA LTBP1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		3479	3488
HPRD ID		00936	00901
Ensembl ID		ENSG00000017427	ENSG00000115461
Uniprot IDs		P05019 Q13429 Q59GC5 Q5U743	P24593
PDB IDs		1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI 4XSS 5U8Q 6FF3 6PYH 6RVA	1BOE 1H59
Enriched GO Terms of Interacting Partners?
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