APOBEC1 and A1CF

Number of citations of the paper that reports this interaction (PubMedID 10669759)
86

Data Source:
HPRD (in vitro, in vivo)

		APOBEC1	A1CF
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 1	APOBEC1 complementation factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex
	Molecular Function	RNA Binding Cytidine Deaminase Activity Cytosine Deaminase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Domain Specific Binding MRNA 3'-UTR AU-rich Region Binding Ribonucleoprotein Complex Binding	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Osmotic Stress Cytidine Deamination Response To Zinc Ion Response To Gamma Radiation Cytidine To Uridine Editing MRNA Modification Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Catalytic Activity Response To Ethanol MRNA Stabilization Response To Calcium Ion Defense Response To Virus DNA Cytosine Deamination DNA Demethylation Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Methylation-dependent Chromatin Silencing Positive Regulation Of MRNA Modification	MRNA Processing Cytidine To Uridine Editing MRNA Modification Protein Stabilization
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		8 interacting genes: A1CF APOBEC2 BAG4 CELF2 DNAJB11 DND1 KPNA2 SYNCRIP	9 interacting genes: APOBEC1 CAVIN2 CELF2 FHL3 KHSRP REL SYNCRIP TNPO2 TRAF1
Entrez ID		339	29974
HPRD ID		02531	10627
Ensembl ID		ENSG00000111701	ENSG00000148584
Uniprot IDs		P41238	A0A024QZI9 A0A024QZJ5 A0A024QZM7 B4E1E3 F8W9F8 Q9NQ94
PDB IDs			2CPD
Enriched GO Terms of Interacting Partners?
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