IARS1 and GARS1

Number of citations of the paper that reports this interaction (PubMedID 8816763)
24

Data Source:
HPRD (two hybrid)

		IARS1	GARS1
Description		isoleucyl-tRNA synthetase 1	glycyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Secretory Granule Axon Extracellular Exosome
	Molecular Function	TRNA Binding Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding GTPase Binding	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Protein Dimerization Activity
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		L-Isoleucine	Glycine
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS
Interacting Genes		6 interacting genes: APP AR EPRS1 ERBB2 GARS1 SNCA	9 interacting genes: CD44 CELSR2 EEF1D HSPB2 IARS1 MAP3K10 MAPK8 NAE1 NEDD8
Entrez ID		3376	2617
HPRD ID		02832	02617
Ensembl ID		ENSG00000196305	ENSG00000106105
Uniprot IDs		P41252 Q6P0M4 Q7L4K8	A0A090N8G0 P41250
PDB IDs			2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?
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