HYAL1 and PRKAR2A

		HYAL1	PRKAR2A
Description		hyaluronidase 1	protein kinase cAMP-dependent type II regulatory subunit alpha
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Exosome	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Transcription Factor Binding Hyaluronan Synthase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Inflammatory Response Response To Virus Positive Regulation Of Epithelial Cell Migration Chondroitin Sulfate Catabolic Process Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Growth Response To Antibiotic Viral Entry Into Host Cell Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Hyaluranon Cable Assembly	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		CS/DS degradation Hyaluronan uptake and degradation MPS IX - Natowicz syndrome	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			GEM-231
Diseases		Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: COL2A1 PRKAR2A	41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1
Entrez ID		3373	5576
HPRD ID		06146	01484
Ensembl ID		ENSG00000114378	ENSG00000114302
Uniprot IDs		A0A024R2X3 A0A0S2Z3Q0 B3KUI5 Q12794	A0A024R2W3 A0A0S2Z472 A8KAH7 P13861
PDB IDs		2PE4	2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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