HTR2A and ANKS1B

Number of citations of the paper that reports this interaction (PubMedID 16537434)
17

Data Source:
HPRD (two hybrid)

		HTR2A	ANKS1B
Description		5-hydroxytryptamine receptor 2A	ankyrin repeat and sterile alpha motif domain containing 1B
Image
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Junction Axon Dendrite Cytoplasmic Vesicle Neuronal Cell Body Dendritic Shaft Cell Body Fiber Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytosol Plasma Membrane Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Intracellular Membrane-bounded Organelle
	Molecular Function	Virus Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Ephrin Receptor Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Viral Entry Into Host Cell Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Synaptic Plasticity By Receptor Localization To Synapse
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone Sertindole Mianserin Asenapine Amisulpride Deramciclane Esmirtazapine Cinitapride Lurasidone Perospirone Amperozide Butriptyline Brexpiprazole Dosulepin Etoperidone Setiptiline Sarpogrelate Ketanserin Nelotanserin Ritanserin Tiapride
Diseases
GWAS		Blood protein levels ( 28240269) Cardiac hypertrophy ( 21348951) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) SjÃ¶gren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)	Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat percentage ( 31752434) Body mass index ( 20966902) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Electrodermal activity ( 25387706) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Response to antipsychotic treatment ( 19721433) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Waist circumference ( 20966902)
Interacting Genes		18 interacting genes: ANKS1B ARF1 ARF6 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	9 interacting genes: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 RIN1 UBC
Entrez ID		3356	56899
HPRD ID		01638	07426
Ensembl ID		ENSG00000102468	ENSG00000185046
Uniprot IDs		P28223	B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8
PDB IDs		6A93 6A94	2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?
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