HSPA6 and DNAJB4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		HSPA6	DNAJB4
Description		heat shock protein family A (Hsp70) member 6	DnaJ heat shock protein family (Hsp40) member B4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Unfolded Protein Binding Misfolded Protein Binding	ATPase Activator Activity Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Response To Unfolded Protein Response To Heat Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)
Interacting Genes		5 interacting genes: ADCK5 CISH CYP4F12 DNAJB4 TERF1	9 interacting genes: HSPA6 MDM2 OPRM1 PABPN1 POLR1D SDIM1 SMAD3 TBL1X TBPL2
Entrez ID		3310	11080
HPRD ID		00775	07486
Ensembl ID		ENSG00000173110	ENSG00000162616
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	B4DNN2 Q9UDY4
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?
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