HP and CD22

Number of citations of the paper that reports this interaction (PubMedID 11967116)
5

Data Source:
HPRD (in vivo)

		HP	CD22
Description		haptoglobin	CD22 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Cytoplasm Early Endosome Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding
	Biological Process	Acute Inflammatory Response Proteolysis Receptor-mediated Endocytosis Defense Response Acute-phase Response Response To Organic Substance Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immunoglobulin Secretion
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Epratuzumab Inotuzumab ozogamicin
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	17 interacting genes: AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK
Entrez ID		3240	933
HPRD ID		00772	00114
Ensembl ID		ENSG00000257017	ENSG00000012124
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	P20273 Q0EAF5
PDB IDs		4WJG 4X0L 5HU6	5VKJ 5VKM 5VL3
Enriched GO Terms of Interacting Partners?
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