APBA2 and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		APBA2	MAPK6
Description		amyloid beta precursor protein binding family A member 2	mitogen-activated protein kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Synaptic Vesicle Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Regulation Of Synaptic Vesicle Exocytosis	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development Cellular Response To Organic Substance
Pathways		Neurexins and neuroligins	MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Response to mTOR inhibitor (rapamycin) ( 24009623) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Temperament ( 22832960)	Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		13 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 LRP1 LRP2 LRP8 MAPK6 NECAB3 NRXN1 RELA STXBP1	166 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TCF12 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		321	5597
HPRD ID		04090	04213
Ensembl ID		ENSG00000034053	ENSG00000069956
Uniprot IDs		Q59G28 Q99767	Q16659
PDB IDs			2I6L
Enriched GO Terms of Interacting Partners?
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