HMGB2 and ZNF668

Number of citations of the paper that reports this interaction (PubMedID 29721183)
2

Data Source:
BioGRID (two hybrid)

		HMGB2	ZNF668
Description		high mobility group box 2	zinc finger protein 668
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Condensed Chromosome Extracellular Space Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Four-way Junction DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Drug Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Response To Drug Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Apoptosis induced DNA fragmentation	Generic Transcription Pathway
Drugs
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Response to metformin (IC50) ( 28173075)
Interacting Genes		37 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 ZNF428 ZNF622 ZNF668	2 interacting genes: DCTPP1 HMGB2
Entrez ID		3148	79759
HPRD ID		01229	07828
Ensembl ID		ENSG00000164104	ENSG00000167394
Uniprot IDs		P26583	A0A024QZD9 A8K1I4 Q96K58
PDB IDs
Enriched GO Terms of Interacting Partners?
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