HLCS and SNX27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HLCS	SNX27
Description		holocarboxylase synthetase	sorting nexin 27
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Mitochondrion Cytosol Nuclear Matrix	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Seasonality and depression ( 30217971)	Body mass index ( 26426971)
Interacting Genes		4 interacting genes: ACACB DDX52 POT1 SNX27	10 interacting genes: AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SLC2A1 VPS26A
Entrez ID		3141	81609
HPRD ID		08360	11591
Ensembl ID		ENSG00000159267	ENSG00000143376
Uniprot IDs		P50747	A0A2R8Y8A7 Q96L92
PDB IDs			4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
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