HLA-DQB1 and CD74

Number of citations of the paper that reports this interaction (PubMedID 16242130)
5

Data Source:
HPRD (in vivo)

		HLA-DQB1	CD74
Description		major histocompatibility complex, class II, DQ beta 1	CD74 molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding
	Biological Process	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Intracellular Protein Transport Defense Response Cell Proliferation Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Kinase Activity Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Cell surface interactions at the vascular wall MHC class II antigen presentation
Drugs		Insulin Pork
Diseases		Type I diabetes mellitus Viral myocarditis Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Acute-on-chronic liver failure in hepatitis B ( 28130311) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 30053915) Asthma ( 21804548 31361310 30929738 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) CCL19 levels ( 25147954) Celiac disease ( 20190752) Cervical cancer ( 28806749) Childhood ear infection ( 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis B infection ( 25802187) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 26956414) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 30500874 26891255 23266558) Diastolic blood pressure ( 27618447) Drug-induced liver injury (flucloxacillin) ( 30661239) Eczema ( 31361310) Emphysema imaging phenotypes ( 26030696) Enteric fever ( 25383971) Eosinophil percentage of granulocytes ( 27863252) Epstein-Barr virus immune response (EBNA-1) ( 23326239) FEV1 ( 30804560) Follicular lymphoma ( 20639881 21533074) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) Height ( 31562340) Hepatitis B ( 21750111 28928442) Hepatitis C (spontaneous viral clearance) ( 30593799) Hepatocellular carcinoma in hepatitis C infection ( 28921602) High altitude adaptation ( 28373541) HPV seropositivity ( 21896673) Hypothyroidism ( 27182965 22493691) IgA nephropathy ( 26028593 25305756) IgE levels ( 23146381) IgG levels ( 28628107) Immunoglobulin A vasculitis ( 28698626) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Knee osteoarthritis ( 20305777) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 1 diabetes ( 30254083) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Lymphoma ( 23349640) Medication use (antihistamines for systemic use) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Moderate to vigorous physical activity levels ( 29899525) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Nephropathy ( 21399633) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417) Oral cavity and pharyngeal cancer ( 27749845) Oropharynx cancer ( 27749845) Parkinson's disease ( 31660654) Peak expiratory flow ( 30804560) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 19458352 20639880) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatoid arthritis ( 24782177 23918589) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 30285260) Self-reported allergy ( 23817569) Sero-negative rheumatoid arthritis ( 28706201) Serum IgE levels ( 25488688) Serum uric acid levels ( 30993211) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097067 28076899) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 26502338) Systemic sclerosis ( 20383147 21779181) Takayasu arteritis ( 23830517) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Tonsillectomy ( 28928442) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 31152121) Type 2 diabetes ( 30054458) Ulcerative colitis ( 24837172 28067908 23128233 19122664) Yeast infection ( 28928442)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		5 interacting genes: CD4 CD74 HLA-DQA1 HLA-DQA2 INS	16 interacting genes: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 MAP3K1 MIF
Entrez ID		3119	972
HPRD ID		05054	00825
Ensembl ID		ENSG00000179344	ENSG00000019582
Uniprot IDs		P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6	P04233
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KSU 5KSV 6DIG	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?